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Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence factors in receiving rivers: Benefits of wastewater treatment plant upgrade

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1682-4

Abstract:

● Abundance of MAGs carrying ARG-VF pairs unchanged in rivers after WWTP upgrade.

Keywords： Wastewater treatment plant upgrade     Antibiotic resistance genes (ARGs)     Virulence factors (VFs)     Geneco-occurrence     Genome-centric analysis    

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Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large spatial scale

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1722-0

Abstract:

● Nitrifiers in WWTP were investigated at large spatial scale.

Keywords： Activated sludge     Spatial distributions     Microbial assembly     Co-occurrence patterns     Nitrifying bacteria    

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A social tag clustering method based on common co-occurrence group similarity

Hui-zong LI,Xue-gang HU,Yao-jin LIN,Wei HE,Jian-han PAN

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 2,   Pages 122-134 doi: 10.1631/FITEE.1500187

Abstract: In this paper, we first present a common co-occurrence group similarity based approach, which employs

Keywords： Social tagging systems     Tag co-occurrence     Spectral clustering     Group similarity http://dx.doi.org/10.1631    

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Vibration-based hypervelocity impact identification and localization Research Article

Jiao BAO, Lifu LIU, Jiuwen CAO,jwcao@hdu.edu.cn

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 4,   Pages 515-529 doi: 10.1631/FITEE.2000483

Abstract: Hypervelocity impact (HVI) vibration source identification and localization have found wide applications in many fields, such as manned spacecraft protection and machine tool collision damage detection and localization. In this paper, we study the synchrosqueezed transform (SST) algorithm and the texture color distribution (TCD) based HVI source identification and localization using impact images. The extracted SST and TCD image features are fused for HVI image representation. To achieve more accurate detection and localization, the optimal selective stitching features OSSST+TCD are obtained by correlating and evaluating the similarity between the sample label and each dimension of the features. Popular conventional classification and regression models are merged by voting and stacking to achieve the final detection and localization. To demonstrate the effectiveness of the proposed algorithm, the HVI data recorded from three kinds of high-speed bullet striking on an aluminum alloy plate is used for experimentation. The experimental results show that the proposed HVI identification and localization algorithm is more accurate than other algorithms. Finally, based on sensor distribution, an accurate four-circle centroid localization algorithm is developed for HVI source coordinate localization.

Keywords： Ensemble learning     Synchrosqueezied transform     Gray-level co-occurrence matrix     Image entropy     Distance    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: To determine whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induceantitumor immunity against tumor cells which express the gene, we constructed mouse tumor cells expressingAfter subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAfter vaccination, tumor occurrence and tumor growth speed was reduced.

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Tracking in urban wastewater treatment plants in a cold region: Occurrence, species and infectivity

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1533-8

Abstract:

• Cryptosporidium in WWTPs in a cold region was investigated in different seasons.

Keywords： WWTPs     Cryptosporidium     Occurrence     Species     Infectivity     Low temperature    

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Occurrence and fate of typical antibiotics in wastewater treatment plants in Harbin, North-east China

Weihua Wang, Wanfeng Zhang, Hong Liang, Dawen Gao

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1118-3

Abstract:

• The concentration distributions and removals of 12 antibiotics were investigated.

• Macrolides and fluoroquinolones presented relatively higher concentrations.

• The removal of antibiotics did not differ among the different treatment processes.

Keywords： Antibiotics     WWTPs     Occurrence     Removal efficiency    

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Antibiotic resistance genes in manure-amended paddy soils across eastern China: Occurrence and influencing

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1499-y

Abstract:

• Manure fertilization resulted in antibiotic residues and increased metal contents.

Keywords： Pig manure     Antibiotics     Metals     Antibiotic resistance genes     Paddy fields    

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Occurrence and removal of

Lin WANG,Yongmei LI,Xiaoling SHANG,Jing SHEN

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 4,   Pages 519-530 doi: 10.1007/s11783-013-0610-4

Abstract: Six wastewater treatment plants (WWTPs) were investigated to evaluate the occurrence and removal of

Keywords： N-nitrosodimethylamine     NDMA precursors     NDMA formation potential     biological treatment process     chemically enhanced primary process    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 3,   Pages 475-481 doi: 10.1007/s11783-014-0640-6

Abstract: Endocrine disrupting compounds (EDCs), pharmaceuticals and personal care products (PPCPs) have attracted much attention due to widespread contamination in aquatic environment. In this study, we determined 13 EDCs and PPCPs in fish blood, bile and muscle by using gas chromatography-mass spectrometry (GC-MS). The limits of quantitation (LOQ) were in the ranges of 0.23–2.54, 0.22–2.36 ng·mL , and 0.24–2.57 ng·g dry weight (dw) for fish blood, bile and muscle, respectively. Recoveries of target compounds spiked into sample matrices and passed through the entire analytical procedure ranged from 65% to 95%, from 60% to 92% and from 62% to 91% for blood, bile and muscle, respectively. The methods were applied to the analysis of fish from a lake in California. Target compounds were relatively low in bile, and only bisphenol A (BPA) and diclofenac were measurable near the LOQ. Seven of 13 compounds were detected in blood, with total concentrations up to 39 ng·mL . Only BPA was frequently found in muscle, with mean concentration of 7.26 ng·g dw. The estimated daily intake of BPA through fish consumption for U.S. resident was significantly lower than the tolerable daily intake recommended by the European Food Safety Authority. This study showed that the exposure to the bisphenol A from fish diet is unlikely to pose a health risk.

Keywords： endocrine disrupting compounds (EDCs)     pharmaceuticals and personal care products (PPCPs)     fish     bisphenol A (BPA)     risk assessment    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Title Author Date Type Operation

Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence factors in receiving rivers: Benefits of wastewater treatment plant upgrade

Journal Article

Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large spatial scale

Journal Article

A social tag clustering method based on common co-occurrence group similarity

Hui-zong LI,Xue-gang HU,Yao-jin LIN,Wei HE,Jian-han PAN

Journal Article

Vibration-based hypervelocity impact identification and localization

Jiao BAO, Lifu LIU, Jiuwen CAO,jwcao@hdu.edu.cn

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Tracking in urban wastewater treatment plants in a cold region: Occurrence, species and infectivity

Journal Article

Occurrence and fate of typical antibiotics in wastewater treatment plants in Harbin, North-east China

Weihua Wang, Wanfeng Zhang, Hong Liang, Dawen Gao

Journal Article

Antibiotic resistance genes in manure-amended paddy soils across eastern China: Occurrence and influencing

Journal Article

Occurrence and removal of

Lin WANG,Yongmei LI,Xiaoling SHANG,Jing SHEN

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article